Abbreviations: AUC, area under the time-plasma concentration curve; BCS, biopharmaceutical classification system; BDDCS, biopharmaceutics drug disposition classification system; CYP, cytochrome P450; GTE, green tea extract; EGCG, C-)-epigallocatechi n-3-gal late; OATP
, organic anion transporting polypeptide; P-gp, P-glycoprotein.
The potential for transporter-mediated DDIs to occur is great, considering, for example, that the widely prescribed statins are substrates for the OATP
uptake transporters and metformin (widely prescribed for type 2 diabetes) is a substrate for OCT-mediated secretion in the kidney.
This is thought to be determined by the expression of OATP
proteins have twelve trans-membrane domains (9) and 388A>G polymorphism is present in one of the extracellular loops (22).
16-18) Additional studies have demonstrated that levofloxacin and other fluoroquinolones are substrates for both P-glycoprotein and OATP