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OATP2Organic Anion Transporting Polypeptide 2
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Unconjugated BS are transported by the multispecific ATP- and [Na.sup.+]-independent basolateral uptake transporters, organic anion-transporting polypeptide 1B1 (OATP1B1, also termed OATP-C, OATP2, SLC21A6, or LST-1, encoded by SLCO1B1), and 1B3 (OATP1B3, synonyms OATP8, SLC21A8, or LST3, encoded by SLCO1B3) [4, 7, 8].
[32] found that, compared to controls, basolateral uptake systems (NTCP, OATP2) were reduced and BSEP and MRP2 were preserved, while MDR1, MDR3, and the basolateral efflux pump MRP3 were increased in PBC.
The human organic anion transporting polypeptide 1B1 (OATP1B1) (gene symbol SLCO1B1, previously OaTP2, OATP-C, and LST-1) [4] is expressed solely on the basolateral membrane of hepatocytes, facilitating the uptake of clinically relevant compounds such as antibacterial drugs, statins, and chemotherapeutic drugs [5].