Balen et al., "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3
on the renal clearance of metformin," Clinical Pharmacology and Therapeutics, vol.
The researchers have found that oct3, which shepherds molecules into and out of cells, plays a critical role by bringing toxic chemicals to the doorstep of the brain cells that die in patients with Parkinson's disease.
They have also shown that oct3 is involved in the brain's response to methamphetamine and other addictive drugs.
The current study has now shown that oct3 as the shepherd that escorts toxic MPP+ out of the astrocytes and into the space surrounding dopamine neurons, which is where another molecule known as the dopamine transporter picks it up and brings it into the neuron itself.
Upon blocking or genetically removing oct3 in mice, the researchers found that the dopamine neurons in the brains did not die despite the presence of MPTP in the brain.
Analysing brain tissue from people who died of Parkinson's disease, the researchers found oct3 to be active in astrocytes in the brain region affected by Parkinson's disease.
In conclusion, we found some functional hub genes, whose encoding protein has a close relationship to AD treatment, such as ErbB2, ErbB4, OCT3
, MIF, CDK13, and GPI.
(BNA) Supreme Council for Youth and Sport (SCYS) first deputy Chairman and head of Bahrain Athletics Association Shaikh Khalid bin Hamad Al-Khalifa today took part the Iron Man and Triathlon Championship, along with Supreme Council for Youth and Sport (SCYS) Chairman and Bahrain Olympic Committee (BOC) President Shaikh Nasser bin Hamad Al-Khalifa.
(BNA) Bahrain is to set up 14 makeshift rural health centres in several parts of the Sudan.
(BNA)His Royal Highness the Premier's Court Chief Shaikh Hosam bin Isa Al-Khalifa today received Busaiteen Sport and Cultural Club First Deputy Chairman and Head of the Executive Bureau Yahya Ali Al-Mujadami, who was accompanied by members of the Follow-up Committee.
(BNA)Marking a new milestone, Bahrain-based Bader Group of Companies hosted the inauguration of the extension of Gulf Membrane and Coating Industries at a special ceremony that was patronized by the Minister of Industry and Commerce Dr.
OCT4, also known as POU5F1, OCT3
, or OTF3, is a nuclear transcription factor expressed in early embryonic cells and germ cells.