The document appropriately identifies that the size of a clinical study should be based on power calculations that use a prevalence ofMI of 10%-20%; however, the example provided uses a prevalence of 20%-25%, which is not likely to be found in an "all comers" emergency department population (prevalence, approximately 10%-15%), thereby underestimating the size of the required clinical study.
Acute and chronic diseases, iatrogenic causes, and myocardial injury have all been found to be related to increased cTn outside of the context ofMI and HF.