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The major prognostic features were cellularity, mitotic rate, and nuclear grade in a 3 step classification by Folpe and Weiss (4) grouping OFMT in a) typical form with low cellularity, mitotic rate <2/50 HPF, and low nuclear grade; b) malignant form with high cellularity and nuclear grade, mitotic rate >2/50 HPF; and c) atypical with intermediate grade between a and b.
(8) described a case showing the classical morphological features of a typical OFMT but metastasized to the lungs.
In our opinion, OFMT deserves to be remembered in the differential diagnosis of subcutaneous masses with these unique features.
(14) Lack of epithelial markers and conspicuous S100 expression with aforementioned histopathologic features are helpful in differentiating an OFMT from a sclerosing epithelioid fibrosarcoma and a synovial sarcoma; the latter displays focal, rather than diffuse, S100 expression.
The etiopathogenesis and exact line of differentiation of an OFMT is presently unclear.
Hanski and Lewicki (21) identified 2 cases of OFMT histologically and ultrastructurally, revealing multinucleated, vimentin and S-100 protein-positive "fibroblastoid" cells.
Twelve years after her initial OFMT diagnosis, the patient presented to an emergency department with left chest and upper shoulder pain.
Given these characteristics, the lesion was classified as an intermediate-grade sarcoma, consistent with an atypical/malignant variant of OFMT.
(8-10) To our knowledge, this is the first report of OFMT metastasizing to the thyroid gland.
Altitudinal range, southern slopes ofMt Kilimanjaro.--900-1000-1500-1800 m.
The absence of these features established this lesion as a usual benign variant of OFMT. The nonneoplastic area adjacent to the tumor showed fibrocystic change.
Cytomorphologic features of OFMT have also been described.
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