OFOTCNOne Flew Over the Cuckoo's Nest (movie/book)
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The role of McMurphy in the 1975 movie OFOTCN was turned down by Kirk Douglas, Marlon Brando, Gene Hackman and Burt Reynolds, but James Caan turned down both that role (which netted an Oscar for JackNicholson) and Dustin Hoffman's role in the 1979 weepie.