In addition to VEGF as the dominant mediator, the soluble receptor sFlt-1 and interleukins also play an important role.4 In accordance with the fact that the pathophysiological process is not sufficiently defined; there is no specific treatment, so the therapy is primarily symptomatic.5 The results of the studies that deal with the effects of severe OHSS
on the outcome of pregnancies are controversial.6,7 The purpose of this study was to examine the risk of preterm birth in female patients with the severe form of OHSS
With clomiphene, viable pregnancy rate was 29.23% (19 cases), spontaneous abortion rate were 06.15% (4 cases), rate of multiple pregnancy were 04.61% (3 cases) & rate of OHSS
were 06.15% (4 cases).
The high basal E2 level has a predictable value in high-risk patients who are young, underweight, have a medical history of OHSS
or polycystic ovarian syndrome, and have high follicles numbers and sizes.
The antagonist given at double-dose before the day of hCG in order to block the OHSS
development decreases the estrogen levels but does not affect pregnancy outcomes (12).
The hallmark of OHSS
is an increase in the permeability of the capillaries, resulting in a fluid shift form the intravascular space to the extravascular compartments.
Laboratory evaluation confirmed OHSS
with the following findings: elevated serum concentrations of CRP (32.9 mg/L), AST (45 U/L) and ALT (48 U/L).
Protocols with GnRH antagonists are most often used for controlled ovarian stimulation (COS) considering that this type of protocol requires less time and bears a lower risk for the development of the ovarian hyper-stimulation syndrome (OHSS
When gonadotropin therapy is not used, the development of spontaneous OHSS
is quite rare and it is usually associated with pregnancy.
In vitro maturation of oocytes has been suggested as an alternative approach to conventional IVF as it completely avoids the risk of OHSS
The lowest effective dose should be used given risk of abnormal ovarian enlargement and Ovarian Hyperstimulation Syndrome (OHSS
Bahra Cables was the first Saudi cable manufacturer to receive ISO 14001:2004 and OHSS
1800:2007 and has extensive involvement with a long list of mega projects across the kingdom Saudi Aramco projects include the Fadhili Gas Plant, Jazan Refinery, Safania LTA project, Marjan, RAMT project in Yanbu.
The Dual Role of PEDF in the Pathogenesis of OHSS
: Negating Both Angiogenic and Inflammatory Pathways.