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OLR1Oxidized LDL (Low Density Lipoprotein)-Receptor 1 (gene)
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Available sequence information from bovine OLR1 gene (Genbank accession no AC_000162) was used to design polymerase chain reaction (PCR) primers.
Investigation of polymorphic loci on the bovine OLR1 gene
In this study, three SNPs (G10563T, T10588C, and C10647T) were identified by pool DNA sequencing in bovine OLR1 gene (Figure 1).
Keeping in view this negation, present study was planned to approximate the rate of evolution of three genes (CYP11b1, SCD and OLR1) in buffaloes.
Primers designed for coding regions of three candidate genes (CYP11b1, OLR1 and SCD) reported by Javed et al.
Phylogenetic trees were constructed for CYP11b1, OLR1 and SCD gene sequences (Figs.
Functional analysis on macrophages suggests a decreased association to OxLDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression [95].
del Vecchio et al., "In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction," Circulation Research, vol.
Results of the study, illustrated that mutations in functionally significant parts of the OLR1 protein affect the high fat content in the buffalo milk.
Key words: OLR1 protein, Homology modeling, Mutations, Functional variants, Buffalo.
The current study aimed to clone the OLR1 gene complete CDS in adipose tissue, analyze OLR1 nucleotide and protein structure characteristics, and subsequently study OLR1 expression in different tissues, different months of age (MA) and different economic types of pig adipose tissue.
According to the gene sequences of OLR1 from related species published in GenBank, we obtained relevant gene assemblage sequences by the EST method using DNAstar software, and then the relevant gene primers were designed by Primer5.0 software.