OLTX

AcronymDefinition
OLTXOrthotopic Liver Transplantation
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They consisted of 7 biopsy specimens that were taken within the first 2 weeks, 10 that were taken between 2 and 6 weeks, 6 that were taken between 6 and 12 weeks, and 2 that were taken between 12 and 24 weeks after OLTx. The number of biopsy specimens varied from 1 to 4 per patient.
The earliest acidophilic bodies were found at 1 week after OLTx, such as acute hepatitis, and there was no portal fibrosis.
The degree of piecemeal necrosis increased with time, and the earliest piecemeal necrosis of moderate degree was observed at 8 weeks after OLTx. One HCV-negative biopsy specimen had mild piecemeal necrosis.
However, there was no lymphoid follicle formation up to 6 months after OLTx. Other features in portal tracts, including bile duct damage and bile ductular proliferation, showed no significant differences between the 2 groups.
The earliest septal fibrosis was observed at 1 month after OLTx, and the fibrosis progressed with time.
The HAI scores showed no significant difference between the 2 groups but increased with time in the HCV-positive group 2 weeks after OLTx (P [is less than] .0344).
One biopsy specimen in the HCV-positive group showed cytomegalovirus hepatitis 12 weeks after OLTx, confirmed by immunohistochemical stain.
Nearly all patients undergoing OLTx for HCV have recurrent viremia, and the levels of HCV RNA continue to increase after OLTx (Figure 5), most likely due to the effect of immunosuppression on viral replication.[13,14] The histopathologic diagnosis of early recurrent hepatitis C is very important, especially during the first few months after OLTx, when immunosuppression is maximal and many other causes may contribute to liver allograft dysfunction, especially cellular rejection.
These findings and the HAI scores increased significantly with time after OLTx and became more significant 8 weeks after OLTx.
The HAI scores in the first 2 weeks after OLTx in both groups were relatively high because of injury during OLTx, such as harvesting injury.