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Conversely, in hippocampal slices of adult mice, treatment with soluble Nogo-A (Nogo66) or OMgp suppressed LTP in an NgR1-dependent manner .
However, effects after injury in NgR1 or Nogo-A, MAG and OMgp knockout mice have been variable [105-107].
After either acute or chronic SCI in rodents, treatment with a soluble NgR1 decoy protein (NgR1(310) ecto-Fc) that neutralizes the effects of all three MAIs (Nogo-A, MAG, and OMgp) has shown promising results in promoting axonal sprouting and functional recovery [112-114].
The rate of remyelination after SCI is likely due to the inhibitory environment and resultant pathology including myelin debris and associated MAIs (NogoA, MAG, and OMgp) which are themselves inhibitory to OPC differentiation [136, 137].
Mikol et al., "Oligodendrocytemyelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth," Journal of Neurochemistry, vol.
Zhang et al., "Oligodendrocyte differentiation and myelination defects in OMgp null mice," Molecular and Cellular Neurosciences, vol.
Strittmatter, "MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma," The Journal of Neuroscience, vol.
Abbreviations AAV: Adeno-associated virus cAMP: Cyclic adenosine monophosphate CNS: Central nervous system CNTF: Ciliary neurotrophic factor CysLT1: Cysteinyl leukotriene receptor 1 GCL: Ganglion cell layer hIL-6: Hyper IL-6 cytokine IL-4R[alpha]: IL-4 receptor a IPL: Inner plexiform layer JAK/STAT: Janus Kinase/Signal Transducers and Activators of Transcription LIF: Leukemia inhibitory factor LTC4: Leukotriene C4 mTOR: Mammalian target of rapamycin NFL: Nerve fiber layer OPL: Outer plexiform layer PTEN: Phosphatase and tensin homolog RGC: Retinal ganglion cell Rheb1: Ras homolog enriched in brain 1 SOCS3: Suppressor of cytokine signaling 3 TLR2: Toll-like receptor 2 MAG: Myelinassociated glycoprotein OMgp: Oligodendrocyte-myelin glycoprotein.
Mikol et al., "Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth," Journal of Neurochemistry, vol.
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