OMTTOpen Multithreaded Transaction (advanced transaction model)
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For the establishment of hyperhomocyst(e)inemia at baseline, we used the local cutoff values for plasma homocyst(e)ine concentrations, i.e., 15 [micro]mol/L (premenopausal women), 19 [micro]mol/L (postmenopausal women), and 18 [micro]mol/L (men) for fasting plasma homocyst(e)ine, and 50 [micro]mol/L for plasma homocyst(e)ine at 6 h during OMTT. For the evaluation of vitamin status, we used our local reference ranges, i.e., whole-blood vitamin [B.sub.6] (55-110 nmol/L), plasma vitamin B1, (170-700 pmol/L), and plasma folic acid (4-30 nmol/L).
Time-dependent changes of fasting homocyst(e)ine and vitamins (day 7 vs day 0; day 14 vs day 7; day 14 vs day 0) and plasma homocyst(e)ine at 6 h during OMTT (day 14 t6 vs day 0 t6) were analyzed with Student paired Mests with Bonferroni adjustment for type 1 errors at P <0.05.
Table 1 shows the baseline concentrations (i.e., data of day 0) for fasting plasma homocyst(e)ine (indicated as t0), plasma homocyst(e)ine at 6 h during OMTT (t6), whole-blood vitamin B6, plasma vitamin [B.sub.12], and plasma folic acid.
Plasma homocyst(e)ine concentrations at 6 h during OMTT (t6) were significantly lower on day 14, as compared with day 0 (P <0.001).
For each of the ensuing deciles, we calculated the means [+ or -] SE for the plasma folic acid and the corresponding homocyst(e)ine concentrations at t0 and at 6 h during OMTT. Fig.
1, top), and with their plasma homocyst(e)ine at 6 h during OMTT (Fig.