The pathogenesis of ONFH was identified with its location on these pillars.
In [Figure 2]a and [Figure 2]b, panels exhibited the concentrated pressure regions that were located in the anterolateral part of the femoral head in all the six three-dimensional geometric models of ONFH.
In other three-dimensional ONFH models, the von Mises stress of necrotic lesions showed smaller values than the critical stress.
The obvious individual differences of corticosteroid-induced ONFH may be the combined effect of corticosteroid on multisystem underlying diseases and host susceptibility.
It is necessary to detect, diagnose, and treat corticosteroid-induced ONFH in its earlier stages.
As the basic principle of disease prevention, the multifactor characteristics of corticosteroid-induced ONFH may require early detection and prevention of femoral head necrosis.
Impaction bone grafting via a window at the femoral head-neck junction, known as the “light-bulb” approach, plays an important role in the treatment of ONFH by providing strong structural support to the subchondral plate and amending the morphology of the femoral head.
ONFH bone defects in one study, in an effort to improve early new bone formation and strengthen the grafted area.
In the sera of patients with ONFH
, the levels of PAI-1 were increased, whereas t-PA levels were significantly decreased.
As shown in [Table 3], elevated blood levels of triglycerides and LDL-C and non-HDL-C, male, urban residence, family history of ONFH
, heavy smoking, heavy drinking, glucocorticoid intake, overweight and obesity were all positively associated with an increased risk of NONFH in our multivariate model.
However, little information about HIV/acquired immune deficiency syndrome (AIDS) and ONFH has been reported in Asia, where the prejudice and fear of HIV may potentially influence the decision to operate.
This retrospective study included 63 hospitalized patients who underwent primary arthroplasty for ONFH from September 2012 to September 2014 in Beijing Ditan Hospital, Capital Medical University.