ORC1Origin Recognition Complex 1
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Abbreviations: ER: estrogen receptor; HAT: histone acetyltransferase; LBD: ligand-binding domain; MYST: MOZ, Ybf1/Sas3, Sas2 and Tip60; Hbo1: a histone acetyltransferase binding to origin recognition complex 1 (ORC1); KAT7: lysine acetyltransferase 7.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.g., CCNB1, PLK1) are coordinately induced and reach maximal expression levels between 8 and 24 hr (Figure 6B), consistent with the timing of the histologic changes observed in Figure 6A.