The rationale of this study was that no local study has been conducted to determine the frequency of HPV in OSCC
which has a huge geographical variation.
Potential of OSCC
to metastasize rests on its ability to break through the basement membrane, to penetrate the surrounding tissues and vascular structures and to bring about new vessel formation for tumor dissemination.
About 65 to 75% of OSCC
patients are linked to smoking, 30% with alcoholism and 26% with betel nut chewing.6-8 Association between genetic factors, poor nutritional status, chronic viral and fungal infections, pre-existing oral disease and bad oral hygiene is also observed in other studies.9-11 Clinically lesion may be ulcerative, exophytic or verrucous.12 Site of involvement is typical for particular risk factor and area exposed to risk factor.13
The study was undertaken to ascertain the frequency of Micronuclei in oral exfoliated cells of normal individuals, patients with PMDs and OSCC
and to assess the role of Micronuclei in diagnosing malignant transformation of PMD.
Previous studies have demonstrated that microRNAs played important roles in OSCC
. For example, microRNA23b/27b cluster is reported as tumor suppressive and regulates the MET oncogene in OSCC
However, there is little known about the role of circRNA in OSCC
The major etiology of OSCC
is the habit of tobacco chewing and smoking.
HNSCC is the sixth most common type of cancer in the world; almost 600,000 cases are reported annually, and of these, [approximately equal to] 10% (or more for some geographic locations) are OSCC
Problem Statement: The survival rate for patients with OSCC
remains poor, despite advances in diagnosis and treatment.
Under this arrangement, OSCC
will provide full-service logistical capabilities, leaving clients to focus on their core business, i.e.
The WT1 gene encodes a zinc finger transcription factor that regulates transcription of growth factor such as PDGF-A and growth factor receptor (IGF-IR) genes and other genes (RAR-*, c-myc and bcl-2).6,7 WT1 promotes cell growth, migration, inhibition and invasion, inhibits apoptosis and induces tumorigenecity in leukemia.8 The pathogenic role of WT1 in OSCC
has not been studied extensively The aim of the study is to investigate the nuclear intensity by WT1 immunomarker in histological grades of OSCC
and its association in tumor cell proliferation.
It is the most common type of cancer in South Asian Countries like India, Srilanka, Pakistan and Bangladesh and contributes nearly onefourth of all new cases of cancer.1 OSCC
is involved in ninety percent of all the malignancies.2 They initiate through rapid uncontrolled division of cancer epithelial cells and once matured gets infiltrated into the adjacent structures, or can disseminate to other organs (secondary metastasis).