The most common potentially malignant disorder was OSMF
, the oral epithelium becomes atrophic and more vulnerable to injury.
Seedat and Van Wyk in 1988 reported that OSMF
also occurs in patients having no history of areca nut chewing.
Initially this condition was limited to subcontinent but because of increase in number of migrants OSMF
is being reported from western countries as well.
is a known entity since centuries.
Clinical diagnosis of OSMF
was based on symptom of burning sensation in mouth upon consumption of spicy or hot foods, repeated vesiculation or ulceration in oral cavity and signs observed were vesicles/ulcers in oral cavity, areas of fibrosis in vestibule of mouth, oral cavity proper and oropharynx, partial or complete inability to protrude out the tongue (ankyloglossia) with or without reduced mouth opening (trismus).
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has a characteristic feature of juxta-epithelial inflammation and fibrosis, mostly along with progressive atrophy of the overlying epithelium, keratinizing metaplasia, increased deposition of hyalinised collagen underneath the basement membrane, and a progressive loss of vascularity to the mucosa giving a pale glossy smoothened look.
extension, but in 2015 it focused its efforts on other developments, and no one took over dash.
The use of areca nut has been strongly implicated as the principal etiological factor in the pathogenesis of OSMF
which involves cytokine mediated collagen synthesis and deposition and reduced collagen degradation.
has been documented in the Indian population since the time of Sushruta--a renowned Indian physician (Circa sixth century BCE) as Vidari, the features of which simulate Oral Submucous Fibrosis, and is more often seen in South Asian countries.