OTBUOptical Transport Business Unit
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Tenders are invited for supply of chemicals of sigma aldrich make or equivalent : Fmoc-Gly-OH >/= 98%,Fmoc-His(Trt)-OH >/= 98.0% CAS ,FMOC-ASPO(OTBU)-OH >/=98.0% CAS NO,FMOC-GLN(TRT)-OH >/=98.0%, CAS NO.
Side-chain functional groups of Fmoc-amino acids were protected with trityl(Trt) (Cys, Ans, and Gln), t-butoxy (OtBu) (Asp and Glu), t-butyl(tBu) (Ser and Thr), t-butyl (oxycarbonyl)(Boc)(Lys and Trp), and 2,2,4,6,7-pentamethyldihydrobenzofuran(Pbf) (Arg).
Protected amino acids Boc-Cys(Trt)-OH (6), BocSer(OtBu)-OH (7), and Boc-His(Boc)-OH (8) were reduced to corresponding alcohols (9-11) using sodium borohydride as we previously described [23].
chemicals: fmoc-asp(otbu)-oh /(n-Ei-fmoc-l-aspartic acid a-t,-butyl ester) (>/-98%) chempep inc, cat.
The following protected amino acids were then added stepwise: [N.sup.[alpha]]-Fmoc-Met-OH, [N.sup.[alpha]]-Fmoc-Arg(Pbf)-OH, [N.sup.[alpha]]-Fmoc-His([N.sub.(im)] trityl (Trt))-OH (or [N.sup.[alpha]]-Fmoc-Gln(Trt)-OH) NT-Fmoc-Gly-OH, [N.sup.[alpha]]-Fmoc-Trp(Boc)-OH, [N.sup.[alpha]]-Fmoc-Glu(OtBu-OH, [N.sup.[alpha]]-Fmoc-Asp(OtBu)-OH, [N.sup.[alpha]]-Fmoc-Phe-OH, [N.sup.[alpha]]-Fmoc-Lys(Boc)-OH, [N.sup.[alpha]]-Fmoc-Ala-OH, [N.sup.[alpha]]-Fmoc-Ser(tBu)-OH, and [N.sup.[alpha]]-Fmoc-Ile-OH.