OVLTOrganum Vasculosum Laminae Terminalis
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The LT including the SFO and OVLT, sensory circumventricular organs lacking the normal BBB, has also been documented as a CNS structure involved in cardiovascular regulation [5].
Evidences have been established that changes in plasma osmolarity were detected by central structures, such as the organum vasculosum of the lamina terminalis (OVLT) and subfornical organ (SFO), and sent through excitatory projection to MnPO [42].
The main central osmoreceptors (OVLT and SFO) and MnPO that are located in the forebrain lamina terminalis [9, 32, 42, 44] target PVN primarily.
The researchers removed a thin slice from a rat's hypothalamus that contained the SCN, the supraoptic nucleus and the OVLT all together.
In response to a 10-day infusion of AngII, we have previously shown that rats with specific lesions of each of the SFO, MnPO, and OVLT have demonstrated an attenuated hypertensive response, implicating each of these sites as having a specific role in the chronic actions of AngII [17-22].
Collectively, these previous studies have (1) demonstrated a role for each of the SFO, MnPO, and the OVLT in the chronic hypertensive response to AngII [17-22] and (2) demonstrated a role for [O.sub.2.sup.*-]--dependent signaling in mediating these effects, thus far, in the SFO and MnPO [23, 24].
In the present study, we hypothesized that elevated levels of [O.sub.2.sup.*-] in the OVLT contribute to the AngII-induced increase in blood pressure observed during peripheral infusion of AngII.
Using a Hamilton syringe, 50 nL of either virus was directly injected into the dorsal OVLT of rats (n = 8 AdCuZnSOD; n = 6 AdEmpty).
CuZnSOD immunofluorescence in the OVLT was imaged with confocal microscopy (Zeiss 510 Meta Confocal Microscope, Carl Zeiss Microscopy GmbH, Jena, Germany).
Adenovirus-Mediated Overexpression of CuZnSOD in the OVLT. Immunofluorescence confocal microscopy was used to confirm overexpression of CuZnSOD in the OVLT in brain sections from rats that received an injection of AdCuZnSOD directly into the OVLT.
CuZnSOD Overexpression in the OVLT Attenuates AngII-Induced Hypertension.
CuZnSOD Overexpression in the OVLT Does Not Affect Sodium and Water Balance in AngII-Infused Hypertensive Rats.