At the end of week 4, both OVX
and SO rats were randomly subdivided into two subgroups that would differ in the amount of regular daily activity and in diet for the next 12 weeks (Figure 1).
In the treatment groups with estradiol and 1000 mg/kg/d of the PG extract, there was a significant increase compared to the OVX-only group (P<0.001) in the average weight and volume of the right femur; the difference was not statistically significant between the OVX
group treated with 500 mg/kg/d of the PG extract and the OVX-only group (P=0.12).
SHAM (g) OVX
(g) Average [+ or -] SD Average [+ or -] SD Uterine weight (g) 1.51 [+ or -] 0.18 0.34 [+ or -] 0.03 Body weight gain (g) 35.58 [+ or -] 11.35 50.58 [+ or -] 13.35 Table II.
Absence of ovarian hormones could lead to increased adipose tissue mass in the body (7, 15) after menopause in humans (16) or OVX
Treatment with high dose MC (OVX+MCHD) significantly lowered (P<0.05) the SBP (106.13 [+ or -] 3.54mmHg) compared to the untreated OVX
group (120.00 [+ or -] 1.62mmHg).
Before memory impairment with scopolamine, ovariectomized rats (OVX
) had a significantly higher (p < 0.001) number of entries into the arms of the Y-maze than normal rats (SHAM 2).
Female mice were either sham-operated or ovariectomized (OVX
) at prepubescence (5 weeks) and were simultaneously implanted with 1 cm of silastic tubing (1.98 mm I.D., 3.18 mm O.D.) filled with 0.5 cm 17[beta]-estradiol (Sigma-Aldrich, St.
Liu et al.'s research indicated that icariin suppressed the differentiation of mesenchymal stem cells into adipocytes via inhibition of peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein [alpha], fatty acid-binding protein 4 mRNA, N1ICD, and jagged1 protein expression and increasing Notch2 mRNA in OVX
rats, which improved osteoporosis .
Therefore, TMX in OVX
mice played agonist activity to effects of the endogenous hormone promoting neutrophil recruitment inhibition in the articular cavity of arthritic mice.
After a 40-week diet treatment, rats were subjected to bilateral OVX
. Followed by a recovery period of 1 week, OVX
animals were administered 17[sz]-estradiol (E[sub]2, 800 [micro]g/kg bw, Sigma, St.
groups received treatment through gastric gavage for 56 days.
Similarly in OVX
gilts fasting for 7 days also reduced serum leptin and LH secretion (Whisnant and Harrell, 2002).