VenatoRx's second development-stage product in clinical development is VNRX-7145, an orally bioavailable BLI that in a fixed combination with the third generation orally bioavailable cephalosporin, ceftibuten, has the potential to rescue activity of the partner antibiotic against ESBLs and key carbapenem-resistant Enterobacteriaceae, including those expressing KPC and
OXA carbapenemases.
With combined disk test, differences in the percentages of false positive results between OXA-23 and OXA-58 and between
OXA 24/40 and OXA-58 were statistically significant (p<0.05 and p<0.001, respectively), as were those with EPI-dilution test (p<0.05 and p<0.001, respectively).
to identify seven different carbapenemase types (KPC, VIM,
OXA, IMP, SPM, SIM, and GIM).
coli isolates belonged to the CTX-M-Group 1 family, TEM and
OXA ESBL genes, while the SHV-type, CTX-M-Group 2, and CTX-M-Group 9 were not detected in any of the tested isolates.
Laying hens Broiler Antibiotic Resistance Sensitive Resistance Sensitive
OXA 57 43 53 47 PEN 79 21 92 8 FOX 57 43 53 47 NEO 10 90 10 90 KAN 0 100 67 33 GEN 3 97 3 97 SXT 21 79 28 72 TCY 44 56 74 26 ENR 21 79 45 55 ERY 55 45 45 55 VAN 0 100 0 100 Bovine Antibiotic Resistance Sensitive
OXA 31 69 PEN 72 28 FOX 31 69 NEO 11 89 KAN 12 88 GEN 0 100 SXT 0 100 TCY 26 74 ENR 87 13 ERY 51 49 VAN 0 100 Oxacillin (
OXA), Penicillin (PEN), Cefoxitin (FOX), Neomycin (NEO), Kanamycin (KAN), Gentamicin (GEN), Trimethoprim/Sulfamethoxazole (SXT), Tetracycline (TCY), Enrofloxacin (ENR), Erythromycin (ERY), and Vancomycin (VAN).
Several analytical methods have been proposed for
OXA determination: most of them use chromatographic techniques and others use fluorometry and capillary electrophoresis; also, some electrochemical sensors have been developed [4-13].
Among various mechanisms of carbapenem resistance
OXA enzymes have become one of the main sources of resistance in recent years [7].
baumannii has now emerged as a pandrug-resistant (PDR) pathogen in Pakistani hospitals.6,7 Among carbapenemases, class D oxacillinases (
OXAs) are the most common8 and less frequent are metallo-b-lactamases (MBLs).9,10
Doxorubicin (DOX, 1 [micro]M) and oxaliplatin (
OXA, 2.5 [micro]M) were used as positive controls.
A total of 11 studies used CKI plus Oxaliplatin (
OXA) + Calcium Folinate (CF) + 5-Fluorouracil (5-FU) regimen.
Detection of OXA-1 beta-lactamase gene of Klebsiella pneumoniae from blood stream infections (BSI) by conventional PCR and in-silico analysis to understand the mechanism of
OXA mediated resistance.