minimum inhibitory concentration; EGCG, epigallocatechin gallate; OXY, oxytetracycline; OXA
, oxacillin; MRSA, methicillin resistant S.
These studies demonstrated that S-649266 has high stability to serine- and metallo-type carbapenemases including KPC, OXA
, IMP, VIM and NDM.
Pseudomonas aeruginosa), the CTX extended spectrum beta-lactamase (ESBL) genetic resistance marker, and the KPC, NDM, VIM, IMP, and OXA
carbapenemase resistance genes from a positive blood culture in two hours.
aureus strain MIC ([micro]g/ml) TET OXA
ERY ATCC 29213 0.
dagger]) NDM (44) NDM-1 (39) Philippines (1), India (1), Thailand (1) NDM-4 (2) None NDM-5 (n2) None NDM-6 (n1) None KPC (38) KPC-2 (32) Argentina (1), Colombia (5), China (4), Ecuador (1), Italy (1), Panama (1), Puerto Rico (4), USA (2), Vietnam (2) KPC-3 (6) USA (3) OXA
-48-like (30) OXA
-48 (28) Jordan (1), Morocco (1), Turkey (10), UAE(1 ) OXA
-163 (1) None OXA
-244 (1) None IMP (2) None IMP-1 (1) None IMP-14 (1) Thailand (1) VIM-1 (2) None Total 41 * NDM, New Delhi metallo-p-lactamase-1 ; KPC, Klebsiella pneumoniae carbapenemase; USA, United States of America; OXA
, oxacillinase; UAE, United Arab Emirates; IMP, imipenemase; VIM, Verona integron-encoded metallo-p-lactamase.
9) VIM, IMP, and OXA
are currently less common than KPC and NDM and are regionally distributed with sporadic outbreaks in Europe, North Africa, Asia, and North America.
Classification of carbapenems (metallo-[beta]-Lactamases--MBLs) Amber Enzyme Function Known organisms class A KPC (1) Hydrolyzes Kpneumoniae, all [beta]- lactam Enterobacteriaceae antibiotics; inhibited by clavulanate B MBLs (2) Hydrolyze all Paeruginosa, (NDM, [beta]-lactams Acinetobacterspp, IMP, except Enterobacteriaceae VIM, aztreonam; GIM, may be SPM) inhibited by clavulanate; require zinc for enzymatic activity; inhibited by EDTA D OXA
Oxacillin P aeruginosa, A hydrolyzing; baumannii, less able to Enterobacteriaceae hydrolyze carbapenems Adapted from Rice LB, Bonome RA.
relate to enzymes derived from TEM-1, SHV-1, or OXA
Worldwide dissemination of the Klebsiella pneumoniae, VIM, OXA
, and New Delhi metallo-b-lactamase type carbapenemases among humans has been facilitated by intercontinental passenger travel, but the role of the global food trade in this dissemination has not been investigated (5,6).
SAT(R) is a matrix drug-in adhesive patch containing 100 mg of diclofenac in 50 sq.
Drug resistance is mediated by extended-spectrum P-lactamases (ES BLs), mainly of the CTX-M family, particularly CTX-M-15 and 14, and less frequently of the SHV and OXA
Federal state 17403 Rhineland- Palatinate 21135 Bavaria 21231 Hessia 24068 Hessia 25044 Bavaria 25147 North Rhine- Westphalia 25470 Bavaria 25715 Hessia 28299 Bavaria 28429 Berlin OXA