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OXPHOSOxidative Phosphorylation (metabolic pathway)
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References in periodicals archive ?
Alteration of expression levels of the oxidative phosphorylation system (OXPHOS) in breast cancer cell mitochondria.
Resting or immature DCs are characterized by their reduced cytokine secretory capacity, priming, and ability to activate T cells, which solely fuel from ATP productions by oxidative phosphorylation (OXPHOS) in mitochondria.
OS: oxidative stress; OXPHOS: oxidative phosphorylation; Mn-SOD: manganese superoxide dismutase; IL-6: interleukin-6; IL-8: interleukin-8; MCP-1: monocyte chemoattractant protein-1; TNF-[alpha]: tumor necrosis factor- [alpha]; IL-1[beta]: interleukin-1[beta]; ROS: reactive oxygen species; A[beta]: amyloid beta.
For analysis of clinical parameters and OXPHOS enzyme expression, t-test or ANOVA and Bonferroni post hoc test were used.
Gnaiger, "High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle," Methods in Molecular Biology, vol.
Dissociation of HK2 from VDAC changed mitochondrial membrane permeability, induced cytochrome c release, inhibited ATP synthesis, blocked OxPhos, caused a drastic reduction of intracellular ATP levels, and stopped ATP-driven membrane pumps, causing an overall irreversible bioenergetic damage leading mitochondria to swell and burst and to cell death (Figure 2) [17, 20, 30].
We used galactose-based medium, which drives the cell toward the OXPHOS system for ATP production, thereby increasing the differences between control and patient fibroblasts (14, 15), for subsequent experiments in fibroblasts.
(53) It contains two strands, a guanine-rich heavy (H) and a cystosine-rich light (L) strand, mtDNA comprises 37 genes of which 13 encode essential components of oxidative phosphorylation (OXPHOS), 22 encode tRNA genes, 1 for 12s and 1 for 16s tRNA genes required for mitochondrial protein synthesis.
Spastic paraplegia and OXPHOS impairment caused by mutations in paralegin, a nuclear-encoded mitochondrial metalloprotease.
They have a four-layer structure, and ROS generation mainly occurs at the electron transport chain (ETC) located on the inner mitochondrial membrane, which folds inward to form a ridge-like shape and called cristae, during the process of oxidative phosphorylation (OXPHOS) [52].
Glucose is a central source of energy and biosynthetic precursors that feed into glycolysis, pentose phosphate pathway (PPP), tricarboxylic acid (TCA) cycle, and oxidative phosphorylation (OXPHOS) [132, 133].
Majority of previous studies about the bioenergetics of malignant tumors were performed in vitro on different cell models with the conclusion that cancer cells have increased glucose uptake and, due to mitochondrial damage, it is not metabolized via oxidative phosphorylation (OXPHOS) [2-4].