containing multiple telemeric TTAGGG motifs suppress inflammasome activity in macrophages subjected to oxygen and glucose deprivation and reduce ischemic brain injury in stroke-prone spontaneously hypertensive rats," PLoS ONE, vol.
Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides
IC31(R) is an adjuvant that induces T-cell and B-cell responses by using a unique synthetic formulation which combines the immunostimulating properties of an anti-microbial peptide, KLK, and an immunostimulatory oligodeoxynucleotide
AV7909, one of the company's next generation anthrax vaccine candidates, is comprised of BioThrax (Anthrax Vaccine Adsorbed) in combination with the immunostimulatory oligodeoxynucleotide
compound CPG 7909 (VaxImmune) licensed from Pfizer Inc.
Tokyo, Japan, Feb 6, 2006 - (JCN) - AnGes MG and Seikagaku jointly announced on February 3 that they have agreed to dissolve their agreement on joint development of NF-kappa B decoy oligodeoxynucleotide
An enema formulation of alicaforsen, a new synthetic oligodeoxynucleotide
antisense molecule, proved to be effective and safe in its first clinical trial in patients with mild to moderately active distal ulcerative colitis.
Results from two studies of ISIS 14803, a 20-nucleotide antisense oligodeoxynucleotide
, given at various dosages to chronic HCV patients as a single-agent therapy through either intravenous or subcutaneous injections from once to three times weekly for up to 12 weeks showed reductions in plasma HCV RNA levels ranging from 1 to 3.
After expression in a host cell polylysine (positively charged moeity) would attract the negatively charged drug, a n oligodeoxynucleotide
, to bind by electrostatic interaction.
mediated inhibition of tobacco mosaic virus RNA translation in vitro.
The companies added that AZD1419 is a proprietary, second-generation TLR9 agonist CpG oligodeoxynucleotide
formulated for inhalation use.
containing TTTCGTTT motif from Lactobacillus rhamnosus GG dna potentially suppresses OVA-specific IgE production in mice.
Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus in chickens adjuvanted with CpG oligodeoxynucleotide