12) Also, there is evidence that opioid-induced hyperalgesia
might limit the usefulness of opioids for controlling chronic pain.
February 18, 2016 -- Cleveland Clinic researchers have found evidence in an animal study that modulating neuro-inflammation with stem cell transplants may prove to be an effective strategy to treat both opioid tolerance (OT) and opioid-induced hyperalgesia
Alternatively, participants prescribed LOT may have experienced near alleviation of pain when first initiating opioid therapy but over time developed opioid tolerance or opioid-induced hyperalgesia
related to the chronicity of opioid therapy, resulting in a rebound of pain [48-49].
The delayed effects of opioids on TRPV1 receptors may also be represented during opioid-induced hyperalgesia
Postoperative patients can develop opioid-induced hyperalgesia
, in which a paradoxical response occurs to opioids and causes increased pain instead of pain management.
in humans; molecular mechanisms and Clinical Considerations Clin J Pain, 2008, 24:479-496.
there is evidence of addiction, tolerance, dependence or opioid-induced hyperalgesia
The impact of opioid-induced hyperalgesia
for postoperative pain.
An additional problem is also introduced with chronic opioid use: opioid-induced hyperalgesia
is a risk in those situations, but even at lower doses, opioids can do more harm than good in depressed pain patients, worsening their quality of life, disability, and state of mind.
First, opioids can cause more sensitivity to pain, a phenomenon known as opioid-induced hyperalgesia
(Ballantyne & Mao 2003).
11, 12 Other possible mechanism may be because of prevention of opioid-induced hyperalgesia
, resulting in reduction of postoperative pain.