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References in periodicals archive ?
Type 2 diabetes alters the functional status of outer hair cells in the cochlea.
10) Radiation-induced vascular insufficiency has been regarded as the etiology of SNHL, while in animal models the exposure of inner ears to radiation resulted in destruction of outer hair cells and inner hair cells, atrophy of the stria vascularis and a reduced number of afferent nerve endings.
The main site of damage is the outer hair cells in the basal turn of the cochlea, where aminoglycosides are received from the lysosomes of the cells' cytoplasm, which leads to the local formation of toxic free radicals and finally to hair cell apoptosis.
Intracochlear administration of thiourea protects against cisplatin-induced outer hair cell loss in the guinea pig.
As outer hair cells become permanently damaged or nonfunctional, otoacoustic emissions provide greater accuracy and efficiency in predicting cochlear status than the audiogram.
DPOAEs depend on the physiological status of the outer hair cells, which are the initial site of ototoxic damage and, therefore, should be sensitive to hearing shifts [31].
1) The damage in hearing are caused by the destruction of outer hair cells and neurons similar to cispalatin toxicity, noise induced hearing loss and perhaps the age-related hearing impairment.
With exposure to loud noise, the outer hair cells show a reduction in their ability to function, which may later recover.
Otoacoustic emissions (OAEs) are active cochlea biomechanisms, which are incidents that require energy, and are caused by outer hair cells and illustrate the sensitivity and frequency selectivity of the cochlea.
Mice lacking FGF20 were missing about twothirds of their outer hair cells.
Dr Sung-Ho Huh, from Washington University in St Louis, whose study appeared in the online Library of Science Biology, said: "This is important because most age-related hearing loss is due to the loss of outer hair cells.
This is the first evidence that inner and outer hair cells develop independently of one another," said lead researcher Dr Sung-Ho Huh, from Washington University School of Medicine in St Louis, US.