p21-activated kinase links Rac/Cdc42 signaling to merlin.
MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions.
Kong et al., "p21-activated kinase
4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Lundin et al., "p21-activated kinase 4 phosphorylation of integrin [beta]5 Ser-759 and Ser-762 regulates cell migration," Journal of Biological Chemistry, vol.
Wells, "P21-activated kinase 4--not just one of the PAK," European Journal of Cell Biology, vol.
A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.
P21-activated kinase 1 plays a critical role in cellular activation by Nef.
Role of p21-activated kinase 1 in regulating the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.
Candidate target genes of hsa-miR-424-5p and hsa-miR-377 Gene name Main pathway Target Accession gene ID hsa-miR-424-5p Hypoxia and angiogenesis HIF1A MIRT005926 CUL2 MIRT005927 Cell cycle CDK6 MIRT000938 CCND1 MIRT000941 CCNE1 MIRT000936 CCND3 MIRT000937 hsa-miR-377 MAPK pathway PPM1A MIRT000990 PI3K-akt pathway PAK1 MIRT000991 HIF1A: Hypoxia-inducible factor 1A; CUL2: Cullin 2; CDK: Cyclin-dependent kinase; CCND1: Cyclin D1; CCNE1: Cyclin E1; CCND3: Cyclin D3; MAPK: Mitogen-activated protein kinase; PPM1A: Protein phosphatase magnesium-dependent 1A; PI3K: Phosphatidyl inositol 3'-kinase; PAK1: p21-activated kinase 1.
Abbreviations GAP: GTPase-activating protein GDI: Guanine-nucleotide dissociation inhibitor GEF: Guanine-nucleotide exchanging factor GST: Glutathione S-transferase JNK: c-Jun N-terminal kinase PAK: p21-activated kinase
PI3K: Phosphoinositide 3-kinase PLC[gamma]1: Phosphoinositol-specific phospholipase C[gamma]1 SH2: Src Homology domain 2 SH3: Src Homology domain 3.
Huang et al., "Signal transduction in Alzheimer disease: p21-activated kinase
signaling requires Cterminal cleavage of APP at Asp664, " Journal of Neurochemistry, vol.
Topisirovic et al., "Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases
(PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway," The Journal of Biological Chemistry, vol.