(redirected from P38 Regulated/Activated Kinase)
PRAKP38 Regulated/Activated Kinase (molecular biology)
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p38 regulated/activated kinase (PRAK) or MAPK activated protein kinase 5 (MK5), ubiquitously expressed in almost all human tissues, is a 471 amino acid protein with 20-30% sequence homology to the known MAPK-regulated protein kinases RSK1/2/3, MNK1/2, and MK2/3 [13].
Abbreviations AD: Activation domain ASK1: Apoptosis signal-regulating kinase 1 DBD: DNA binding domain ERK3: Extracellular signal-regulated kinase 3 FRET: Fluorescence resonance energy transfer GST: Glutathione S-transferase HSP27: Heat shock protein 27 MAPK: Mitogen-activated protein kinases MAPKAPK5: Mitogen-activated protein kinase activated protein kinase 5 NES: Nuclear export sequence Ni-NTA: Nickel-nitrilotriacetic acid NLS: Nuclear localization sequence PRAK: p38 regulated/activated kinase.