After normalization with [beta]-actin (internal control), fold changes in the expression levels of target mRNAs (COX-2, iNOS, I[kappa]B, p65, p38a
, JNK, and ERK1/2) were calculated using the [2.sup.-[DELTA][DELTA]CT] method.
Taylor, "Oral administration of the p38a
MAPK inhibitor, UR13870, inhibits affective pain behavior after spinal cord injury," Pain, vol.
as an example, results of five percentiles 1%, 2%, 5%, 10%, and 15% of the total phosphorylation sites number are compared, as shown in Figure 5.
TGF-[sz]1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38[sz] to proapoptotic p38a
. Mol Cancer Res 2012;10:605-14.
Few years ago, benzophenones with para-methoxy substitutions were assessed as p38a
inhibitors and were found to have high selectivity and efficacy .
MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance.
In Tomorrow Never Dies, Elliot Carver chased Bond through the streets of Saigon in a Range Rover P38A
; Bond stole a Range Rover Sport in Casino Royale as a last-minute trick to set off car alarms.
Tan et al., "Amide-based inhibitors of p38a
Alonso et al., "Essential role of p38a
MAP kinase in placental but not embryonic cardiovascular development," Molecular Cell, vol.
Van Eldik, "Microglial p38a
MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (A[beta]), " Journal of Neuroinflammation, vol.
(2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38a
The second-generation vehicle, known as the P38a
, went on sale in 1994 and was replaced in 2001 by the current model.