P38AProline 38 Replaced with Alanine
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After normalization with [beta]-actin (internal control), fold changes in the expression levels of target mRNAs (COX-2, iNOS, I[kappa]B, p65, p38a, JNK, and ERK1/2) were calculated using the [2.sup.-[DELTA][DELTA]CT] method.
Taylor, "Oral administration of the p38a MAPK inhibitor, UR13870, inhibits affective pain behavior after spinal cord injury," Pain, vol.
Taking P38A as an example, results of five percentiles 1%, 2%, 5%, 10%, and 15% of the total phosphorylation sites number are compared, as shown in Figure 5.
TGF-[sz]1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38[sz] to proapoptotic p38a. Mol Cancer Res 2012;10:605-14.
Few years ago, benzophenones with para-methoxy substitutions were assessed as p38a inhibitors and were found to have high selectivity and efficacy [6].
p38a MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance.
In Tomorrow Never Dies, Elliot Carver chased Bond through the streets of Saigon in a Range Rover P38A; Bond stole a Range Rover Sport in Casino Royale as a last-minute trick to set off car alarms.
Alonso et al., "Essential role of p38a MAP kinase in placental but not embryonic cardiovascular development," Molecular Cell, vol.
Van Eldik, "Microglial p38a MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (A[beta]), " Journal of Neuroinflammation, vol.
(2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38a protein.
The second-generation vehicle, known as the P38a, went on sale in 1994 and was replaced in 2001 by the current model.