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Alder is also developing ALD1910, a preclinical mAb designed to inhibit pituitary adenylate cyclase-activating polypeptide (PACAP) for migraine prevention.
PACAP and the PAC1 receptor inpost-traumatic stress disorder.
Neurotrophic effects of PACAP in the cerebellar cortex.
De Felici, "Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells," Development, vol.
[23.] Zhou R, Tsang AH, Lau SW, Ge W (2011) Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the zebrafish ovary: evidence for potentially dual roles of PACAP in controlling final oocyte maturation.
Wu, "Neuroprotection of a novel cyclopeptide C*HSDGIC* from the cyclization of PACAP (1-5) in cellular and rodent models of retinal ganglion cell apoptosis," PLoS ONE, vol.
Many drugs show neuroprotective effects for stroke treatment, including NMDA receptor antagonist, calcium antagonists, and pituitary adenylate cyclase-activating polypeptide (PACAP) [15,16].
Vaudry et al., "Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells," Journal of Neurochemistry, vol.
VIP is structurally related to the secretin/glucagon family of peptides and hormones, sharing 70% sequence identity with the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) .
Menetrey, "Cyclophosphamide cystitis as a model of visceral pain in rats: a c-fos and Krox-24 study at telencephalic levels, with a note on pituitary adenylate cyclase activating polypeptide (PACAP), "Experimental Brain Research, vol.
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- Paca, William
- PACAF Integrated National Exploitation System
- PACAF Jungle Survival School
- Pacamor Kubar Bearings
- Pacaraima Mountains
- PACAREA Command Enlisted Advisor
- Pacaya Samiria Amazon Lodge
- Pacaya Samiria National Reserve
- Pacbitun Regional Archaeology Project
- Pacc Isn't Another Counter-Strike Clan