The team of scientists led an international consortium that carried out a genome-wide association study (GWAS) of 1,854 PACG cases and 9,608 controls of over five sample collections in Asia.
A total of 1,293 Singaporeans with PACG and 8,025 Singaporean controls were enrolled in this study.
Prof Aung has worked on PACG for over 10 years and believes from clinical observations that the disease is strongly hereditary.
The information on genes involved in PACG
has also opened up new and exciting research areas for us that we hope will culminate in new treatment modalities for angle closure glaucoma in the future," Said Dr Eranga Vithana, Associate Director, Basic and Experimental Sciences at SERI, and lead author of the paper.
MYOC gene may not be playing a significant role in causing POAG and PACG
in our population.
56-58) Patients with PACG
usually present with an acute attack, which is associated with severe ocular pain, blurred vision, redness, headaches and nausea.