PAF-AHPlatelet Activating Factor Acetylhydrolase
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2+]-independent PLA2; PAF-AH, platelet-activating factor acetylhydrolase; AD, Alzheimer disease; CSF, cerebrospinal fluid; bis-Bodipy FL [C.
The gene that encodes the enzyme PAF-AH is located on chromosome 6q21.
These results suggest that the V279F mutation of plasma PAF-AH may be a genetic risk factor for atherosclerotic diseases.
Most instances are due to a Ioss of function mutation (Val279Phe, exon 9, position 994; G'T) in the plasma PAF-AH gene (7).
The study found that PAF-AH levels were significantly lower in patients who died of peanut anaphylactic reactions than in all other control groups.
All study participants underwent carotid Doppler ultrasonography and laboratory testing, including lipid traits, PAF-AH activity, and DNA isolation.
The hypercholesterolemic patients divided in the two IMT groups had the same percentages of risk factors, which would provide better evidence on the role of PAF-AH gene polymorphisms and activity on the assessment of carotid atherosclerosis.
PAF-AH activity was measured by a spectrophotometric assay, with detection at 405 nm (Auto PAF-AH-AZ-01; kindly provided by R & D Division, Nesco Company, Azwel Inc.
In view of the ability of HDL to protect LDL against oxidation, the aim of our study was therefore to investigate the activities of serum paraoxonase/arylesterase and PAF-AH in patients with chronic renal failure and hence to assess whether changes in activity might contribute to the accelerated development of atherosclerosis.
PAF-AH activity was determined by using 2-[acetyl-[sup.
PAF-AH as a therapeutic candidate shares characteristics common with several successful biotech products on the market today.