2+]-independent PLA2; PAF-AH
, platelet-activating factor acetylhydrolase; AD, Alzheimer disease; CSF, cerebrospinal fluid; bis-Bodipy FL [C.
The gene that encodes the enzyme PAF-AH is located on chromosome 6q21.
These results suggest that the V279F mutation of plasma PAF-AH may be a genetic risk factor for atherosclerotic diseases.
Most instances are due to a Ioss of function mutation (Val279Phe, exon 9, position 994; G'T) in the plasma PAF-AH gene (7).
The study found that PAF-AH
levels were significantly lower in patients who died of peanut anaphylactic reactions than in all other control groups.
Fluvastatin slow-release lowers PAF-AH
activity: a placebo controlled trial in patients with type 2 diabetes.
All study participants underwent carotid Doppler ultrasonography and laboratory testing, including lipid traits, PAF-AH activity, and DNA isolation.
The hypercholesterolemic patients divided in the two IMT groups had the same percentages of risk factors, which would provide better evidence on the role of PAF-AH gene polymorphisms and activity on the assessment of carotid atherosclerosis.
PAF-AH activity was measured by a spectrophotometric assay, with detection at 405 nm (Auto PAF-AH-AZ-01; kindly provided by R & D Division, Nesco Company, Azwel Inc.
In view of the ability of HDL to protect LDL against oxidation, the aim of our study was therefore to investigate the activities of serum paraoxonase/arylesterase and PAF-AH in patients with chronic renal failure and hence to assess whether changes in activity might contribute to the accelerated development of atherosclerosis.
PAF-AH activity was determined by using 2-[acetyl-[sup.
as a therapeutic candidate shares characteristics common with several successful biotech products on the market today.