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PAK2P21-Activated Kinase 2 (enzyme)
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Some genes involved in signal transduction (such as CNTNAP2, STMN2, PAK2, and SMOC2), calcium ion binding (such as CAMTA1, PCDH9, CDK5R1, and SYT1), MAPK signaling pathways (SPRED1), I-kappaB kinase/NF-kappaB signaling pathways (VAPA), and transport (such as VAMP4, SLC5A11, SLC4A4, COX1, and COX3) were identified.
These experiments confirmed that the genes EDG1, PAK2, and the previously unidentified TRAC-1 were normally expressed in the lymphoid system and that truncated versions of their proteins could repress T-cell receptor signaling in T-cells.