To supplement these results, the researchers completed a case-control study on 1633 individuals with dementia (case) and 1810 without any dementia symptoms (control), all taken from the initial PAQUID
Characteristics of the PAQUID
cohort living in the urban area of Bordeaux, 1988-1997.
The PAQUID research programme is funded by the `Fondation de France', Sandoz Laboratories, AXA Insurance Company, the French Ministry of Research and Technology, the National Medical Insurance Companies CNAMTS and MSA, the Brain Institute (ARMA), the Regional Council of Aquitaine, the General Councils of Gironde and Dordogne, the Regional Direction of Sanitary and Social Affairs of Aquitaine, the Inter-Firms pension aid fund, CAPIM-MEC and INSERM, the National Institute of Medical Research.
Health measures correlates in a French elderly community population: the PAQUID study.
The design of the PAQUID survey does not allow the assay of urinary iodine content, but study of subjects' records indicated a highly significant association between an abnormal TSH level and the use of an iodinated drug: 4/26 subjects with high and 1/18 with low TSH level versus 4/381 with normal TSH were taking such drugs [[[Chi].
Further assessment of the subjects of the PAQUID cohort will provide data on the evolution of both the thyroid and psychological functions, as it has been shown [38, 41] that borderline increased TSH may return to the normal range some months later.
In the PAQUID study, alterations of cognitive functions seem more frequent in patients with sub-clinical hypothyroidism than in subjects with normal or low TSH levels, but the difference was not statistically significant.
The PAQUID project is an epidemiological study of cerebral and functional ageing, by the follow-up of 4134 French elderly people for at least five years.
The aim of the present study was to estimate the risk of one-year incident dementia in elderly subjects living in the community, included in the PAQUID study, as a function of their performance on the four IADL, score at baseline.
The PAQUID study, includes three waves: two samples of community, dwellers, randomly selected in the administrative areas of Gironde and Dordogne, and a sample of institutionalized old people, randomly, selected in 42 institutions in Gironde.
In these parishes 4050 subjects aged 65 and over, living in the community, were randomly selected from electoral rolls, stratified by age and sex; (2792 (69%) gave their written consent to participate in the PAQUID study.
The general methodology of the PAQUID study has been published elsewhere[16, 24].