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PAR3Protease-Activated Receptor-3
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In a previous study, the researchers showed that inactivation of the polarity protein Par3 resulted in a decline of stem cells, impaired skin homeostasis and premature skin aging.
Zhou et al., "Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis," The Journal of Biological Chemistry, vol.
The mechanism by which activated PAR1 is recruited to clathrin-coated pits is presently not clear, and whether internalization of PAR2, PAR3, and PAR4 proceeds through the same pathway as PAR1 or is regulated by distinct mechanisms remains to be established.
com3, com4 Participation par1, par2, par3, par4 H2: participation has a direct, Cocreation cocre1, cocre2, positive impact on cocreation.
Coughlin, "Protection against thrombosis in mice lacking PAR3," Blood, vol.
megacephala, se disectaron y montaron en laminas, luego se fotografiaron, digitalizaron, y se ubicaron ocho puntos anatomicos de referencia en la nervadura de las venas del ala (PAR1-PAR8), los cuales corresponden con el tipo I sensu Bookstein (1991), siguiendo la nomenclatura de McAlpine (1987), ruptura de la subcosta (PAR1), union de R1 con el borde del ala (PAR2), union de [R.sub.2+3] con el borde del ala (PAR3), union de [R.sub.4+5] con el borde del ala (PAR4), union de M con el borde del ala (PAR5), union dm-cu (PAR6), union de Cu con dm-cu (PAR7) y union de M con bm-cu (PAR8).
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En cada ala se ubicaron seis puntos anatomicos de referencia (PAR 1-6), los cuales corresponden con el tipo I sensu Bookstein (1991): Base de la vena transversal cu-pcu (PAR1), Base de la vena transversal m-cu (PAR2), doblez de la vena m (PAR3), intercepcion de la vena R + Sc (PAR4), Apice de la vena M (PAR5) y apice de la intercepcion cu-Pcu (PAR6).
The localization of homologs of PAR6 and PAR3 to a cortical actin cap near the meiotic spindle and establishment of polarity has been reported for mouse oocytes (Vinot et al., 2004; Duncan et al., 2005), which may be also required for spindle migration.
In another similarity with AJ development, the apical determinant Crb is also crucial for the development and localization of TJs in vertebrate epithelia, by recruiting the polarity proteins Par3, Par6, and associated proteins to the apical margin of the epithelium (Macara, 2004).
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