PARK1P-Adrenergic Receptor Kinase 1
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A defect in the PARK1 gene can cause the concentration of the protein alpha-synuclein to become so high that clumps deposit around and damage dopamine-producing cells.
Div Two: (3pm) Admrial v Kelma Oval 2, SAB V Big House Upton Park1. Div Three: (3pm) FC Village v Bronze Social Levers 1, Wirral Wanderers v Smart Energy Coronation 2.
Jae-Suk Lee, Young-Sun Cho, Jin-Woo Lee, Hyun-Jung Kim (1), Do-Gi Pyun (1), Myung-Hwan Park1, Taek Rim Yoon (2), Ho-Jin Lee (3) and Yoshimitsu Kuroyanagy (4)
Tenders are invited for Repairs and Improvements to Kamakotti Nagar Park,Astalakshmi Ngr Park, Arumugam Ngr 3rd Main Road Park, VGP Shanthi Nagar Park in Dn 189 and Chettinad Enc Park1, Chettinad Enc Park2, Dr.Ambedkar Ngr Park in Dn 190 and Jayachandiran Ngr Park in Dn 191
An abnormal interaction with components of chaperone-mediated autophagy-dependent degradation (Lamp2a, Hsc70, and Hsp90) results in accumulation of chaperone-mediated autophagy substrates, such as [alpha]-synuclein (a-syn, PARK1, and PD-related gene), in cells [133].
PARK1 for example encodes a-synuclein, which can inhibit mitochondrial fusion [143].