PARK1P-Adrenergic Receptor Kinase 1
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References in periodicals archive ?
A defect in the PARK1 gene can cause the concentration of the protein alpha-synuclein to become so high that clumps deposit around and damage dopamine-producing cells.
Div Two: (3pm) Admrial v Kelma Oval 2, SAB V Big House Upton Park1. Div Three: (3pm) FC Village v Bronze Social Levers 1, Wirral Wanderers v Smart Energy Coronation 2.
Jae-Suk Lee, Young-Sun Cho, Jin-Woo Lee, Hyun-Jung Kim (1), Do-Gi Pyun (1), Myung-Hwan Park1, Taek Rim Yoon (2), Ho-Jin Lee (3) and Yoshimitsu Kuroyanagy (4)
An abnormal interaction with components of chaperone-mediated autophagy-dependent degradation (Lamp2a, Hsc70, and Hsp90) results in accumulation of chaperone-mediated autophagy substrates, such as [alpha]-synuclein (a-syn, PARK1, and PD-related gene), in cells [133].
PARK1 for example encodes a-synuclein, which can inhibit mitochondrial fusion [143].