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Peripheral nerve impairment is associated with markers of chronic lead exposure, TWA and IBL, but not PbBn, and may be present when recent PbB is at an acceptable concentration.
Minimum- Variable Mean [+ or -] SD maximum Age (years) 44 [+ or -] 8.4 24 to 64 Education (years) 8 [+ or -] 2.8 0 to 13 Years employed 20 [+ or -] 5.3 4 to 26 Current alcohol users (%) 60 -- Current smokers (%) 14 -- PbB ([micro]g Pb/dL) 26 [+ or -] 7.1 13 to 43 IBL ([micro]g-year/dL) 891 [+ or -] 298.8 81 to 1,376 TWA ([micro]g Pb/dL) 42 [+ or -] 8.4 17 to 57 PbBn ([micro]g Pb/g bone mineral) 40 [+ or -] 23.8 -12 to 90 CP[T.sub.2000] Hz (mA) 330 [+ or -] 72.4 180 to 512 CP[T.sub.250] Hz (mA) 134 [+ or -] 50.5 32 to 278 CP[T.sub.5] Hz (mA) 83 [+ or -] 37.9 16 to 190 Values are mean [+ or -] SD except where noted.
More recently, studies have shown an association between several biomarkers of chronic lead exposure--working lifetime-weighted average blood lead (TWA), working lifetime-integrated blood lead (IBL), and bone lead (PbBn)--and impairment of peripheral nerve function at a time when concurrent PbB was not elevated (Chia et al.
The Human Subjects Committee at the University of Maryland, Baltimore, approved the PbBn protocol.
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