Pre-B cell colony enhancing factor (PBEF
), a cytokine with multiple physiological functions.
Bu onemli gelismeden once, bir sure sessiz bir donem geciren ve fizyolojik rolu uzerinde cok yorum yapilmayan bu protein, ilk zamanlarda 'pre-B cell colony-enhancing factor (PBEF
)' olarak adlandirilmisti.
Insanlarda visfatin ilk kez 1994 yilinda Sa-mal ve arkadaslari tarafindan kemik iligi stromal hucrelerinde aktive lenfositlerden salinan ve erken evre B hucre olusumunu stimule etmek uzere IL-7 ve kok hucre faktoru ile sinerjik etki gosteren bir protein olarak kesfedilmis ve PBEF
(Pre-B cell colony-enhancing factor) olarak tanimlanmistir (3-5).
The adipokine visfatin was initially identified in lymphocytes and is therefore also called pre-B-cell colony-enhancing factor (PBEF
Zhou, "Expression of pre-B-cell colony enhancing factor and its influence on the expression of PBEF
, TNF-[alpha], IL-1p and NF-[kappa]B p65 in pulmonary tissues of rats with ARDS," Journal of Chongqing Medical University, vol.
 as "a novel human pre-B-cell colony-enhancing factor (PBEF
)." Visfatin consists of ten introns and eleven exons that are spanned over 34.4 Kb of genomic DNA.
Visfatin was identified in the liver, skeletal muscle, and bone marrow as a growth factor for B cell precursors and a pre-B-colony enhancing factor (PBEF
Visfatin levels were estimated by mouse visfatin / PBEF
ELISA kit, Circulex (MBL International, USA) by quantitative sandwich enzyme immunoassay technique.
Visfatin is a 52 kDa protein originally established as pre-B cell colony-enhancing factor (PBEF
) (Samal et al., 1994; Rongvaux et al., 2002).
The new adipokine, eNampt, mainly secreted by visceral fat, facilitated early B cell proliferation as pre-B-cell colony-enhancing factor (PBEF
) at first  and drew considerable interest; after that it was described as an insulin-mimetic cytokine and termed as visfatin .
Visfatin also known as PBEF
(pre-B-cell colony enhancing factor) or Nampt (nicotinamide phosphoribosyl-transferase) was discovered in 2005 by Fukuhara et al.
Visfatin, also known as pre-B-cell colony-enhancing factor (PBEF
) and nicotinamide phosphoribosyltransferase (Nampt), was originally described as a cytokine involved in early B-cell development and was later renamed visfatin since it is secreted mainly by visceral fat .