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Resistance of Pseudomonas aeruginosa to antibiotics (including carbapenems) may depend on several mechanisms such as: loss of porins (OprD), presence of active systems removal of drugs, modification of receptor binding antibiotic (PBP3 and PBP4) and the ability to produce [beta]-lactamases [3-5, 15].
It has high affinity for PBP1, PBP2, and PBP4 of Staphylococcus aureus as well as for PBP2, PBP3 and PBP4 of Escherichia coli and Pseudomonas aeruginosa.
coli as compared to PBP3 and has good affinity for PBP1a and PBP1b.
For example, in group G1 isolates, the percentage of densitometric values of PBPs ranged between 30-63 per cent (PBP1); 33-63 per cent (PBP2); 68-83 per cent (PBP3); 11-91 per cent (PBP4); 66-16 per cent (PBP5); 86-98 per cent (PBP6); 49-69 per cent (PBP1); 95-99 per cent (PBP8) with reference to the respective PBP expression in ATCC.
Prestressed Continuous Concrete, Single Column, Box Girder; PBP3
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- PBP C3