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Firstly, population-based reference ranges (PBRRs) of these indices show clinically relevant changes with increasing age  but the PBRRs which are often used in daily practice were determined in a non-aged population.
If this were the case, the interpretation of laboratory tests might be improved by applying subject-specific reference ranges (SSRRs) instead of PBRRs, as has been advocated for healthy elderly subjects [13-15].
All the variables studied are often used in PBRRs since `normality' holds true.
In two of these patients SSRRs were equally sensitive and in two patients SSRRs were more sensitive than PBRRs in judging the measured creatinine concentrations.
PBRRs had a limited diagnostic value in detecting dehydration in these patients, which is in agreement with this high individuality.
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- PBR Forces Veterans Association, Inc.
- PBR FVA
- PBR PI