Predictive value of PCA3
in urinary sediments in determining clinico-pathological characteristics of prostate cancer.
The aims of this study were to evaluate the clinical performance of the urinary PCA3
assay in a clinical setting with men at high risk of PCa, to assess the correlation between PCA3
score and tumor aggressiveness, to achieve an optimal PCA3
cutoff score for PCa detection, and to provide a logistic regression model for better detection of PCa by combining urinary PCA3
score with serum PSA level and other demographic and clinical variables such as age, race, family history, digital rectal examination (DRE) findings, and prostate volume.
), a very sensitive and specific marker to detect prostate tumors.
score of 20 could improve prostate cancer detection: results obtained on 734 Italian individuals.
The last two populations Ain Abid x Rmada (P18) and Ain Abid x El-Wifak (P20) were also distinguished by high values of chlorophyll content, flag leaf area, spikes fertility, and harvest index, relatively to PCA2 but were associated with low number of ears, relatively to PCA3
(Figures 1 and 2).
score, PSGR score, and MALTA-1 score were significantly higher in PCa patients than in patients with negative biopsies (P = 0.0001 and 0.0001, resp.; Figure 1).
Asset Sale will allow Hologic to control all assets related to the PCA3
biomarker and, upon closing of the Transaction, will result in an immediate cash payment to DiagnoCure.
Stephenson may order tests such as the prostate cancer antigen-3 (PCA3
) urine assay or magnetic resonance imaging (MRI) before recommending a repeat biopsy.
The first circulating lncRNA, for which assays with clinical utility have been developed, is the prostate cancer associated 3 (non-protein coding) (PCA3
) gene, which was found to specifically diagnose patients with prostate cancer (20, 21).
Of these potential tests, only the Prostate Cancer Gene 3 (PCA3
) test is commercially available.
(144) In prostate cancer, the clinical importance of ncRNAs came to the forefront with the discovery that PCA3
, a long ncRNA located on band 9q21, is a promising prostate cancer biomarker.
is a molecular diagnostic test performed on urine rather than blood and detects mRNA that is excreted into the urethra via the epithelial cells that line the prostatic ducts.