Genetic instability of tumor cells may lead to altered expression of apoptotic proteins and immune-regulatory molecules, such as transforming growth factor-beta (TGF-ss).8 Spontaneous regression of LyP is seen almost universally, whereas regression occurs in approximately 25% of pcALCL
Kim and his coauthors concluded that the implant-associated ALCL follows a course that is closer to PCALCL
than to the systemic ALK-negative disease.
This is the fifth FDA-approved indication for ADCETRIS, which also has regular approval for adult patients with: (1) classical Hodgkin lymphoma (cHL) at high risk of relapse or progression as post-autologous hematopoietic stem cell transplantation (auto-HSCT) consolidation, (2) cHL after failure of auto-HSCT or failure of at least two prior multi-agent chemotherapy regimens in patients who are not auto-HSCT candidates, (3) sALCL after failure of at least one prior multi-agent chemotherapy regimen, and (4) primary cutaneous anaplastic large cell lymphoma (pcALCL
) or CD30-expressing mycosis fungoides (MF) who have received prior systemic therapy.
All patients were suffering from relapsed CD30-positive cutaneous lymphoproliferative disorders, including lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL
) or mycosis fungoides (MF).