PCALCLPrimary Cutaneous Anaplastic Large Cell Lymphoma (cancer)
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Genetic instability of tumor cells may lead to altered expression of apoptotic proteins and immune-regulatory molecules, such as transforming growth factor-beta (TGF-ss).8 Spontaneous regression of LyP is seen almost universally, whereas regression occurs in approximately 25% of pcALCL cases.
Kim and his coauthors concluded that the implant-associated ALCL follows a course that is closer to PCALCL than to the systemic ALK-negative disease.
All patients were suffering from relapsed CD30-positive cutaneous lymphoproliferative disorders, including lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL) or mycosis fungoides (MF).