PCDAIPediatric Crohn's Disease Activity Index
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The disease severity in patients was measured using the pediatric Crohn's disease activity index (PCDAI) and ranged from 7.5-70.
For the years 2012 and 2013, the frequency of clinic visits was extracted along with the corresponding clinical disease activity scores (PCDAI or PUCAI) for each visit.
The patients were all in remission phase (PUCAI score = 11.85 [+ or -] 5.16 and PCDAI score = 4.25 [+ or -] 2.3) and their CRP, ESR, and WBC and PLT counts were in normal range (Table 2).
HBI, PCDAI and LS scores all significantly declined.
An unpaired t-test was used to compare platelets, albumin, haematocrit, PCDAI, height for age z-scores, and weight for age z-scores between the two groups.
In addition blood samples for full blood count (FBC) and C-reactive protein (CRP) were taken to calculate the PCDAI. CRP (normal range 0-4 mg/l) is measured at our institution rather than ESR.
El PCDAI se desarrollo y se valido en 1991, pues se demostro como una herramienta util para estudios multicentricos en ninos y adolescentes con EC (41.) El PCDAI analiza 11 variables (3 basadas en datos clinicos, 3 en datos analiticos y las 5 restantes en la exploracion fisica) (Cuadro 5).
Univariate analysis demonstrated that a more severe disease course was associated with low albumin, high PCDAI scores, initial hospitalization, initial corticosteroid use, and incomplete response to initial therapy.
Data were collected at baseline and week 8, including basic demographics, history, physical examination, the PCDAI, and laboratory findings.
However, M2-PK levels did not correlate with PCDAI scores or serum inflammatory markers.
Disease activity was measured by physicians' general assessment on a 4 point scale (1=no activity/remission and 4 = severe activity) and by calculation of the Pediatric Crohn's Disease Activity Index (PCDAI) for patients with CD and the Pediatric Ulcerative Colitis Activity Index (PUCAI) [18, 19].