Serrero, "Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF
, epithelin/granulin precursor)," Proceedings of the National Academy of Sciences of the United States of America, vol.
It is worth to mention the presence of an additional ligand capable of incorporating both TNF-R1 and TNF-R2 with still increasing importance in the pathogenesis of OA, which is progranulin (PGRN) also known as granulin epithelin precursor (GEP), PC-cell derived growth factor (PCDGF
), proepithelin (PEPI), or acrogranin [77-80].
Progranulin, also known as granulin/epithelin precursor (GEP), acrogranin, and PC cell-derived growth factor (PCDGF
), is a 593 amino acid growth factor [1, 2].