We retrospectively selected 33 case-patients on the basis of PCHL outcome to analyze a broad parasite clearance distribution with available cryopreserved isolates.
All except 4 isolates from patients who had PCHL >5 h had a single K13 mutant allele (19/23), and all isolates except 1 (G538V) from case-patients who had PCHL <5 h carried the K13 3D7 wild-type allele (9/10).
Previous reports have inconsistently associated the N458Y mutation with ART-R; 7 case-patients with PCHL >5 h were reported by Ashley et al.
[GREEK TEXT NOT REPRODUCIBLE IN ASCII] PCHL
; 134 [GREEK TEXT NOT REPRODUCIBLE IN ASCII] RVBAld [GREEK TEXT NOT REPRODUCIBLE IN ASCII] PCHL
; 276 [GREEK TEXT NOT REPRODUCIBLE IN ASCII] RVBAld vs.
Chukar is resistant to strawbreaker foot rot and carries the Pchl
gene for resistance, derived from Roazon, as indicated by the presence of the Epl-D isozyme marker (McMillin et al., 1986).