PCLBCLPrimary Cutaneous Large B Cell Lymphoma
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Seven cases of PCLBCL were studied (Table 2) that included 3 males and 4 females ranging in age from 11 to 59 years (mean, 39 years).
The large B cells in our PCLBCL cases resemble and have a immunophenotype similar to that of the large interfollicular B cells, recently described in reactive lymph nodes, (14) and shown to be immunoreactive for CD20, with negative staining for CD5, CD23, CD10, BCL-6, and CD38.
(11) The pattern of immunoreactivity can be both cytoplasmic and nuclear.11 The pattern of staining in our cases of PCLBCL was similar to that demonstrated in normal lymphoid tissue in previous reports.