PCSKProprotein Convertase, Subtilisin/Kexin
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PCSK9 is a typical PCSK in that it has a serine esterase-like structure of the bacterial subtilase family but differs in that it shares similarity with proteinase K.
3] Nonstandard abbreviations: PCSK, proprotein convertase subtilisin/kexin proprotein; FH, familial hypercholesterolemia; LDL-R, LDL receptor; FH, familial hypercholesterolemia; ER, endoplasmic reticulum; EGF, epidermal growth factor; LDL-C, LDL cholesterol; SREBP, sterol responsive element binding protein; HMG CoA R, hydroxymethylglutaryl coenzyme A reductase; TGN, trans Golgi network; SRE, sterol regulatory element; GWAS, genome-wide association studies; TG, transgenic; KO, knockout; APP, amyloid precursor protein; BACE1, [beta]-site APP-cleaving enzyme 1; HCV, hepatitis C virus; mAb, monoclonal antibody.
Many PCSKs have the ability to negatively regulate cell surface receptors, namely LDL-R and CD81, used by viruses to gain access the cell membrane and infect the host.