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Between the pre-PCV7 and PCV13 time periods, the researchers found significant reductions in the mean rates of OM visits of 48% and 41% among children younger than 2 years and younger than 5 years, respectively; reductions were 24% and 22%, respectively, when comparing PCV13 and PCV7. Ambulatory care visits for skin rash and trauma were not significantly different among the study periods.
PCV7 vaccine was implemented in the NIP in November 2008 as a 3+1 dose schedule at 2, 4, 6 and 12 months.
(3) While in our study, DTaP-IPV-Hib had the lowest proportion of children completing the series (85%), in the provincial birth cohort, PCV7 was the lowest at 75%.
(v) the shape of decrease in PCV7-types IPD following PCV7 introduction and of PCV13-7 IPD following PCV10 + PCV13 introduction maybe approximate by a negative exponential function [14-16];
1, the introduction of PCV7 in SA in 2009, followed by PCV13 in 2011, led not only to a dramatic reduction in penicillin- (82%) and ceftriaxone-resistant (85%) pneumococcal infections, but also to multidrug-resistant (MDR) disease (84%). These remarkable results are supported by the matched case-control study by Cohen et al., confirming that PCV may have a substantial impact on reducing the prevalence of MDR pneumococcal disease, as has been demonstrated in other settings.
The coverage rates of PCV7, PCV10, and PCV13 serotypes were 58.2%, 58.2% and 84.1%, respectively (Fig.
The annual number of hospitalizations for pneumonia of Tennessee children aged <2 years were >2,000 in 1998 and 1999, before PCV7 introduction, and declined to <1,000 by 2010 through 2012, after introduction of PCV13 (Table 1).
pneumoniae serotypes causing IPD in Mexico were covered by PCV7, whereas 77% were covered by PCV13 (3).
In the current vaccine schedule, PCV13 is recommended for routine vaccination at ages 2, 4, and 6 months, with a booster at age 12-15 months; a single supplemental dose is recommended for children aged 14-59 months who have had an age-appropriate series of PCV7.
Rates of meningitis declined most dramatically among children, probably because of the introduction of the PCV7 vaccine.
The studies also showed that measles-mumps-rubella-varicella vaccine (MMRV) and pneumococcal conjugate vaccine (PCV7) can be administered concomitantly with Menactra vaccine in children.
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