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PDE4BPhosphodiesterase 4b
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References in periodicals archive ?
(2005) DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
The genetic change interfered with Pde4B's ability to break down a molecular messenger called cAMP.
Dr Alexander McGirr, a psychiatrist in training at the University of British Columbia, added: "In the future, medicines targeting PDE4B may potentially improve the lives of individuals with neurocognitive disorders and lifeimpairing anxiety, and they may have a time-limited role after traumatic events."
[sup][10],[11] In monocytes and macrophages, it has been well documented that inhibition of PDE4 effectively suppresses LPS-induced tumor necrosis factor-a (TNF-a) production, [sup][12],[13],[14],[15],[16] and this effect is mediated through inhibition of PDE4B. [sup][17],[18] Thus, it was hypothesized that targeting a single PDE4B subtype may retain efficacy but reduce the side effects of nonselective PDE4 inhibitors.
Christensen et al., "Suppression of human inflammatory cell function by subtypeselective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B," The British Journal of Pharmacology, vol.
PDE4B is involved in controlling the negative pathway.
Since PDE4B is expressed by lung cells, we sought to determine whether inhibiting PDE4B decreased fluid accumulation during ARDS.
AI172064 56646 Lgals1 Lectin, galactose 3' binding, soluble 1 J02810 24423 Gstm1 Glutathione S-transferase, mu 1 X04229 H32189 565355 50672 Ednrb Endothelin receptor type B X57764 AA818970 U09540 25426 Cyplbl Cytochrome P450 1b1 X83867 AI176856 M14972 50549 Cyp4a10 Cytochrome P450, 4a10 AA924267 D83538 64161 Pik4ca Phosphatidylinositol 4-kinase U39572 J04563 24626 Pde4b Phosphodiesterase 48, cAMP-specific [dunce (Drosophila)- homolog phospho- diesterase E4] M25350 X81395 29225 Cesl Carboxylesterase 1 U10697 (a) http:/www.ncbi.nih.gov/GenBank/.
Anti-PDE4 antibodies were purchased from Abcam (PDE4A: cat#: ab14607; PDE4B: cat#: ab14611; PDE4C: cat#: ab97356; PDE4D: cat#: ab14613, Abcam, Inc., Cambridge, MA, USA).
Two other genes--dubbed PDE4B and PKC-beta--are more active in patients in whom the lymphoma is ultimately fatal than in the other group, the researchers report.
The genes containing very highly selective SNPs with p-value <0.01 (nearly top 1% SNPs) in all traits and p-value <0.001 (nearly top 0.1%) in any traits were phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2), and ADAM metallopeptidase domain 12 (ADAM12).