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At day 35, FGF-2, [alpha]-SMA and PDGF expressions increased in BLM-treated lung tissue were determined by western blot.
14) Anusaksathien et al in 2003 reported that in an ex vivo investigation, the expression of PDGF genes was prolonged for up to 10 days in gingival wounds.
Adult animals lacking expression of the beta cell PDGF receptor were also less able than their peers to regenerate beta cells that were artificially damaged by a chemical compound, and they became severely diabetic after such treatment.
Early consolidation of the graft: the increased amount of PDGF in the graft initiates osteocompetant cell activity at an enhanced molecular rate.
They are using it to see which cells make PDGF and when.
Working both in cultured cells and diabetic animals, the researchers traced a molecular cascade that ends up increasing the expression of a novel target, the protein SHP-1, which de-activates PDGF activity and thus triggers cell death.
The company will use the proceeds from the contract for the development of an inhaled PDGF receptor kinase inhibitor to treat pulmonary arterial hypertension (PAH).
The very compelling and robust results of this well-executed study validate PDGF as an important target for wet AMD and set the stage for a new era of combination therapy via co-formulation or fixed-combination delivery.
Proceeds from the contract will be used to develop an inhaled PDGF receptor kinase inhibitor for the treatment of pulmonary arterial hypertension (PAH).
All Augment branded products are based upon recombinant human platelet-derived growth factor (rhPDGF-BB), which is an engineered form of PDGF, one of the body's principal agents to stimulate and direct healing and regeneration.
Inhibition of PDGF is one such pathway and we are looking forward to developing a potential combination therapy together with Regeneron.
HIF-2 regulates downstream genes including VEGF, EGF, PDGF, TGF-, and bFGF, which play a role in the progression of a broad range of tumors.
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- PDGF A-chain
- PDGF receptor
- PDGF subunit A
- PDGF subunit B
- PDGF, B chain
- PDGFA-Associated Protein 1