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The clubbing may have been improved as a result of increased blood flow, but it is also possible that the symptoms were improved by the inhibition of the release of cytokines such as PDGF, VEGF or HGF by immunosupressive therapy.
Mineralization of collagen matrix is speeden up due to PDGF that is present in the graft material, instead of being released from collagen.
Activated platelets release PDGF, a potential smooth muscle cell mitogen (6, 24).
c-Abl, a tyrosine kinase implicated in chronic myelogeous leukemia (the Philadelphia chromosome), appears to be activated in patients with SSc, perhaps reflecting TGF-[beta] and/or PDGF stimulation.
1] Nonstandard abbreviations: SELEX, systematic evolution of ligands by exponential enrichment; PDGF, platelet-derived growth factor; NP, nanoparticle; BB, B-chain homodimer.
The [alpha] form of the PDGF receptor in particular binds PDGF with high specificity, resulting in growth stimulation through interactions with the ras oncogene.
are described for determining the level of expression of genes for specific types of PDGF receptor
These effects, together with imatinib's suppression of c-kit and PDGF receptors, may help to explain the exacerbation of psoriasis in some patients (5), (6), (7), (8), (9).
The researchers found that the expression of PDGF receptors was also reduced in pancreatic islet cells from juvenile mice in a pattern similar to the reduction in beta cell proliferation.
The innovative Kuros "TG-hook" technology enables the PDGF to be retained at the site for local exposure to migrating cells and for sustained delivery of PDGF on enzymatic cleavage of the matrix.
During repair platelets become entrapped in a fibrin clot and degranulate releasing two primary growth factors: PDGF and TGF-B.
Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City.
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- PDGF A-chain
- PDGF receptor
- PDGF subunit A
- PDGF subunit B
- PDGF, B chain
- PDGFA-Associated Protein 1