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PDGFBPlatelet-Derived Growth Factor, Beta Polypeptide
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(e, f) Expression of TGF[beta]1 and PDGFb mRNA was detected in the proximal colon using quantitative real-time reverse transcription polymerase chain reaction.
Cells grown on the biopaper had significantly higher expression of PDGFB (p = 0.007) and claudin 1 (CLDN1, p = 0.047) but significantly lower expression of VCAM1 (p = 0.017) at this time point.
Incremento en la produccion de Activacion de NF[kappa]B radicales libres de oxigeno en Incremento en la produccion de las celulas de musculo liso moleculas quimiotacticas vascular Expresion aumentada de moleculas Mayor adhesion de celulas de adhesion (ICAM) inflamatorias Expresion del receptor viral Union de quimioquinas US 28 Migracion celular incrementada Incremento en la expresion Aumento en la atraccion de de MCP-1 monocitos Incremento de la expresion del Elevacion en la captacion de LDL receptor "Scavenger" en Incremento en la acumulacion de membrana lipidos en la celula de musculo liso vascular Expresion del receptor de PDGFb Proliferacion de celulas de musculo liso vascular Inhibicion de la actividad de Inhibicion de la apoptosis en la la proteina p53 placa aterosclerotica.
There are four causal genes identified so far, including solute carrier family 20 member 2 ( SLC20A2 ), platelet-derived growth factor receptor beta ( PDGFRB ), platelet-derived growth factor subunit B ( PDGFB ), xenotropic and polytropic retrovirus receptor 1 ( XPR1 ).[2] In this study, we reported a familial IBGC pedigree caused by a novel SLC20A2 mutation.
Paraffin sections were incubated with rabbit primary antibodies to Fn14, Ki-67, platelet-derived growth factor subunit B (PDGFB), CD3, Iba-1, or phospho-epidermal growth factor receptor (pEGFR) (2 [micro]g/ml; Abcam, Cambridge, MA, USA).
Numerous studies of restenosis have indicated that transforming growth factor beta 1 (TGF-[beta]1), platelet-derived growth factor beta (PDGFB), epidermal growth factor (EGF) [19], basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) play an important role in VSMC proliferation and migration to the tunica intima [20].
The primary antibody (1: 200 diluted) against VEGF or PDGFB was added and incubated at 4[degrees]C overnight.
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities.
(68-73) In one such study, a mouse model in which transgenic Gfap promoter-driven expression of PDGFB was superimposed upon a Tp53-null background not only generated GBM-like lesions in mice, but also intriguingly demonstrated hyperplastic astroglial lesions in both subependymal and subpial locations, possibly representing precursor lesions.
Mutations in SLC20A2 , PDGFRB , XPR1 , and PDGFB have been reported to cause primary familial brain calcification (PFBC).
Pdgfb and Fgf2 both stimulate MSC proliferation and migration of MSC, while inhibiting their adipogenic and osteogenic differentiation [40, 41, 45].