PDGFR


Also found in: Medical.
AcronymDefinition
PDGFRPlatelet Derived Growth Factor Receptor
References in periodicals archive ?
'We believe the updated data from our ongoing Phase 1 clinical study, with the additional six months of maturity from our last Phase 1 data cut-off, continue to support ripretinib's potential across the broad range of KIT and PDGFR mutations known to occur in patients with GIST following therapy with imatinib,' said Steve Hoerter, President and Chief Executive Officer of Deciphera.
The most common primary mutations are in KIT kinase, representing approximately 75% to 80% of cases, or in PDGFR? kinase, representing approximately 5% to 10% of cases.
The drug action was not influenced by the blocking of FGFR, PDGFR, and VEGFR function, thus demonstrating that the 2 mechanisms are uncoupled.
A number of studies have found elevated expression of several cellular growth factors and their receptors in NETs: VEGF, VEGF receptor (VEGFR), platelet-derived growth factor (PDGF), PDGF receptor (PDGFR), stem cell factor receptor (c-KIT), and epidermal growth factor receptor (EGFR) [96].
The oral administration of CM082 is more convenient than intravitreal injection, and its inhibition of both VEGFR and PDGFR might be more effective than anti-VEGF injections alone.
Toceranib possesses antiangiogenesis and antitumor activity due to its potent inhibition of targets, including VEGFr, PDGFr, and KIT [19].
Previously, studies have revealed that rosmarinic acid and luteolin repress platelet-derived growth factor receptor (PDGFR) and endothelial growth factor receptor (EGFR) (Kim et al.
leydig cells) are controlled by growth factors like SCF, PDGF and their interaction with tyrosine kinase receptors (PDGFR and c-kit) (1-5).
Various proteins have been suggested as markers for CAFs, including [alpha]-smooth muscle actin (SMA) [3], tenascin-C [4], chondroitin sulfate proteoglycan (NG2) [5], platelet-derived growth factor receptor (PDGFR)[alpha]/[beta] [6], fibroblast activation protein (FAP) [7], podoplanin [8], prolyl 4-hydroxylase [9], and fibroblast-specific protein- (FSP-) 1 [5].
Immunohistochemically, the tumor was strongly positive for CD34 (figure 4, A) and bcl-2 (figure 4, B), mildly positive for phosphorylated protein kinase B (pAKT) and phosphorylated extracellular signal-regulated kinase 1/2 (pERK 1/2), and negative for pan cytokeratin(AEl/AE3),EMA, platelet-derived growth factor receptor (PDGFR) alpha and p53.
FLT3 (Fms-like tyrosine kinase-3), also known as FLK2 (fetal liver kinase-2) and STK1 (human stem cell kinase-1), was originally isolated as a hematopoietic progenitor cell-specific kinase and belongs to Class-III receptor tyrosine kinase (RTK) family to which c-Fms, c-Kit, and the PDGFR (platelet derived growth factor receptor) also belong [1].