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PDK1Phosphoinositide-Dependent Kinase-1 (also seen as PDK-1)
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References in periodicals archive ?
NF-[kappa]B, nuclear factor-[kappa]B; GSK-3[beta], glycogen synthase kinase 3-[beta]; MUC1-C, mucin 1-C; TERT, telomerase reverse transcriptase; STAT5, signal transducer and activator of transcription factor 5; HIF-2[alpha], hypoxia inducible factor-2[alpha]; IL-6, interleukin-6; PDK1, pyruvate dehydrogenase kinase 1.
To determine the effects of E2 on cDC metabolism, we chose two biomarkers of metabolic activation of the cDCs, Pdk1, and nitric oxide (NO).
Alessi, "PDK1, the master regulator of AGC kinase signal transduction," Seminars in Cell & Developmental Biology, vol.
MI-1 could inhibit such protein kinases as Yes, Src(h), ZAP70, Syk(h), PDK1, EGFR, IGF-1R, VEGFR, and so forth as evidenced by [7, 8].
[PIP.sub.3] acts as a second messenger and allows the anchoring in the plasma membrane and activation of proteins with PH (pleckstrin homology) domains, like PDK1 (phosphoinositide-dependent protein kinase 1).
Similarly, we have found that F9 cells maintained in the undifferentiated state have high levels of LDHA and PDK1 (manuscript in preparation) (Figure 4).
Gong et al., "3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis," Proceedings of the National Academy of Sciences of the United States of America, vol.
NnV dramatically decreased phosphorylation of PI3K, PDK1, and Akt at Thr308, whereas it significantly upregulated the expression of PTEN.
Chou, "COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPfi pathway and PDK1 stabilization" Oncotarget, vol.
PDK1, a protein kinase that phosphorylates and thus inactivates pyruvate dehydrogenase alpha subunit, was more than 2-fold over expressed in frataxin knockdown cells.
Four isoforms of PDK (PDK1, PDK2, PDK3 and PDK4) phosphorylate specific serine residues on the [alpha]-subunit of E1 and two isoforms of PDP (PDP1 and PDP2) dephosphorylate the residues.